Induction of Apoptosis by Xanthones from Mangosteen in Human Leukemia Cell Lines

Xanthones from Mangosteen in Human Leukemia Cell Lines

There is Scientific Evidence that suggests that Human Leukemia Cell Lines show an Induction of Apoptosis by Xanthones from Mangosteen.
Get the full report here:http://scienceasia.org/2007.33.n3/v33_283_292.pdf

Orally, mangosteen is used for dysentery, diarrhea, urinary tract infections (UTI), gonorrhea, thrush, tuberculosis, menstrual disorders, stimulating the immune system, cancer, osteoarthritis, and improving mental health. Topically, mangosteen is used for eczema and other skin conditions.

The applicable parts of mangosteen are the fruit, juice, rind, bark, and twigs. The fruit and juice are consumed as a healthful and medicinal food and drink. The dried and powdered rind is most commonly used for medicinal purposes. The bark extract, called Amibiasine, is used for amebic dysentery.

Mangosteen fruit, rind, and bark seem to contain several pharmacologically active constituents. The activity of some of these isolated constituents has been characterized. But there is no reliable information about the effects of eating the whole fruit or taking the powdered rind or bark extracts.

The mangosteen rind reportedly contains tannins. Tannins can have an astringent effect on mucosal tissue and can reduce secretions. This astringent effect might reduce diarrhea.

Mangosteen also contains xanthones that have antioxidant and other effects. The specific xanthones include alpha-mangostins, beta-mangostins, and gamma-mangostins (12016). Alpha- and beta-mangostins appear to have in vitro activity against the human leukemia cell line HL60 (12013) and Mycobacterium tuberculosis (12014). Mangosteen also contains the xanthone derivatives garcinone B and garcinone E. These constituents also appear to have in vitro activity against Mycobacterium tuberculosis (12014). Garcinone E also has in vitro cytotoxic activity against hepatocellular carcinomas (12015).

Mangosteen is a tropical fruit. Its fruit is sourly sweet. It's often consumed as a dessert fruit or made into jams.

It was thought to be Queen Victoria's favorite fruit.

Mangosteen juice is becoming a popular healthful and medicinal drink. Some marketers claim that Mangosteen juice can treat diarrhea, menstrual problems, urinary tract infections, tuberculosis, and a variety of other conditions.

There is no reliable scientific evidence to support these claims.

However, there is Scientific Evidence that suggests that Human Leukemia Cell Lines show an Induction of Apoptosis by Xanthones from Mangosteen.
Get the full report here: http://scienceasia.org/2007.33.n3/v33_283_292.pdf