Thursday, September 18, 2008

Mangosteen Research For Diabetics

This is some research by Dr Kay Davies, who has a PhD in Physiology



Mangosteen has been shown, in a recent laboratory study, to slow the breakdown of starch (carbohydrates) to sugar in the same way as the Diabetic drug, Acarbose (Brand names – Prandase or Precose). Slower breakdown of starch results in less sugar (glucose) in the blood immediately following eating. Additional studies have shown that Mangosteen is retained in the blood for up to 6 hours – maximum effectiveness occurs 1-3 hours after taking Mangosteen.

Thus, Diabetics are recommended to take their Mangosteen 1-3 hours prior to their largest meal, or with this meal. Mangosteen, taken at the correct time will also help non-Diabetics by reducing the extra strain excess sugar puts on the Pancreas. This extra strain on the Pancreas, in time, can lead to Diabetes.


The Diabetic medication, Acarbose*, works by inhibiting the enzyme (Amylase) that is primarily responsible for the breakdown of Starch to Sugar ( Glucose).

A study** has shown that the one of the Xanthones in the Mangosteen Pericarp works in exactly the same way in our body as Acarbose.

Starch consists of unbranched glucose molecules (Amylose) and branched glucose molecules (Amylopectin). One of the Xanthones in the pericarp of Mangosteen inhibits the enzyme, Amylase. Amylase is inhibited with both Acarbose and Mangosteen, so that the amount of Starch broken down to Sugar from eating is greatly reduced. This means that the sugar level of Diabetics is lessened immediately after a meal. The starch in what was consumed is broken down more slowly over time, after Acarbose and Mangosteen disappear from a person’s blood.

Mangosteen works exactly the same way as Acarbose without any drug side effects.
For Diabetics, the best time to take Mangosteen is to take it within 1-3 hrs prior to eating, or with a meal. If a Diabetic is only taking one dose of Mangosteen, they should take their Mangosteen prior to their largest meal.

Non-Diabetics also benefit from taking Mangosteen. This is because diets which contain excess sugar put an unnecessary strain on the Beta cells in the pancreas. Over time, this excess strain has been shown to result in insulin resistance, leading to full blown Diabetes. Taking Mangosteen on a regular basis reduces the amount of sugar in the blood following meals high in carbohydrates and sugars, and thus prevents this strain on the pancreas.

Additional studies have shown that Mangosteen is retained in the blood stream for at least 6 hours – maximum effectiveness occurs in the first 1-3 hours.CONCLUSION

Mangosteen and the drug, Acarbose, both result in the slower breakdown of starch to sugar. This leads to everyone having less sugar in their blood following a meal. Less sugar to deal with means it is easier for Diabetics (and non-Diabetics) to move the sugar present in the blood into their cells – less insulin needs to be released and the sugar level remains closer to normal. Another benefit of taking Mangosteen versus Acarbose is there are no drug side-effects.

REFERENCES Brand Names for Acarbose: Prandase or Precose
Journal of Agricultural and Food Chemistry 2007 Nov 28; 55(24):9805-10. Assay-guided fractionation study of alpha-amylase inhibitors from Garcina mangostana pericarp.

Mangosteen will give one maximum results if it is in liquid form, and also contains Vitamins and Minerals in the same formulation. Mangosteen, minerals, vitamins taken in capsule or tablet form are not readily absorbed and utilized by the body.

Brunswick Laboratories 2008. Bioavailability and antioxidant effects of the Vemma formula in humans.

Vemma contains whole fruit
Mangosteen Juice and pericarp extract. Go here for more information and to purchase Vemma Mangosteen Juice

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